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Dapoxetine is a novel oral medication undergoing FDA review for premature ejaculation, one of the most common disorders of sexual dysfunction in men. Dapoxetine is a fast-acting inhibitor of the serotonin reuptake transporter. It has a short half-life and is structurally related to the antidepressant fluoxetine, allowing for on-demand dosing. Recent phase 3 clinical trials in patients with premature ejaculation have shown Dapoxetine to be effective in improving the time to ejaculation without any major adverse events, except nausea. If approved, Dapoxetine would be the first drug specifically indicated for premature ejaculation, and it may offer patients a safer and more tolerable alternative compared to traditional selective serotonin reuptake inhibitors (SSRIs), which are currently used off-label to treat this condition.

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Dapoxetine, Actinex, Aczone, Dapoxetin, Dapoxetina, Dapsone, Dejac, Duraject, Duralast, Poxet, Priligy, Tadapox, Viglast, Westoxetin, Xydar,

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Sat, the secreted autotransporter toxin of uropathogenic Escherichia coli, is a vacuolating cytotoxin for bladder and kidney epithelial cells. The results indicate that the molecular properties of a given promoter, rather than the chromosomal topology, dictate the responsiveness to changes in supercoiling in the pathogen Staphylococcus aureus. This review discusses the damaging events that ultimately may lead or contribute to telomere shortening and can be associated with metabolic diseases. Comparison of three summary statistics for ranking genes in genome-wide association studies.

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The induction and characterization of rat liver stearyl-CoA desaturase mRNA. As control group, 33 age- and-sex-matched healthy children (HC) were also examined. The effects of inferior vena caval ligation on cardiac output: an experimental study. Kinetics of the MNZ removal by PPN was found to follow a two-parameter pseudo-first-order decay model well, and the activation energy of the MNZ degradation by PPN was determined to be 30.49kJ/mol.

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The effects of lateral prefrontal transcranial magnetic stimulation on item memory encoding. Clinical improvement with levodopa therapy for PD is associated with specific regional changes in cerebral glucose metabolism. It is necessary to provide more information about the matter, especially in hospitals where there is a preclinical xenotransplantation program or where there is access to one, such as in the hospitals in this study. Temporomandibular joint involvement in a cohort of patients with Juvenile Idiopatic Arthritis and evaluation of the effect induced by functional orthodontic appliance: clinical and radiographic investigation.

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In this study, beta- and gamma-tubulin expression under various stages of differentiation was measured in an in vitro generated arsenite-resistant L. Primary choriocarcinoma of the stomach is an extremely rare and highly malignant tumor. Metabolic peculiarities of the citric acid overproduction from glucose in yeasts Yarrowia lipolytica. Spontaneous subdural hematomas associated with meningiomas are rare, specially related to the microcystic variant of meningioma.

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Synthesis, characterization and antibacterial activity of polyaniline/Pt-Pd nanocomposite. The structures primarily affected in patients with 22q11DS are derivatives of the embryonic pharyngeal arches and pouches suggesting that haploinsufficiency of the gene(s) on the deleted region, spanning 2-3 Mb, is important in pharyngeal arch/pouch development. The possible mechanisms of stimulation of cyanobacterium growth by the passage through the Carassius auratus intestine: an experimental study.

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The current 2007 WHO classification, therefore, assigns grade II to the cerebellar liponeurocytoma. Recent developments in the area of innate immunity broaden current concepts of genetically defined factors in host-pathogen interactions. Optimum dimensions of parallel-hole, multi-aperture collimators for gamma-ray cameras. Ambient temperature was negatively related to both morning and evening PEF and FEV1 for 0-3 days lag. To test the hypothesis that salt-sensitive hypertension reflects an abnormal response of rifafour overdose on vitamin the sympathetic nervous system (SNS) to salt, arterial pressure and plasma norepinephrine (NE) concentration were measured in 23 black hypertensive patients and 28 black normotensive control subjects during 4 days of salt depletion and 3 days of salt loading.

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