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Rats were given methylcellulose (vehicle), fenofibrate or Pioglitazone (35 mg/kg body weight/day) by gavage for 4 months. For patients with type 2 diabetes mellitus and metabolic syndrome, combined treatment with metformin and rosiglitazone or Pioglitazone is safe and effective, However, the Pioglitazone combination also reduced the plasma Lp(a) levels whereas the rosiglitazone combination did not.

Other names for this medication:
Pioglitazone, Astrozone, Glita, Glustin, Opam, Pepar, Tiazac, Zactos,

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Pioglitazone is an anti-diabetic drug (thiazolidinedione-type, also called "glitazones") used along with a proper diet and exercise program to control high blood sugar in patients with type 2 diabetes. It works by helping to restore your body's proper response to insulin, thereby lowering your blood sugar. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke. Pioglitazone is used either alone or in combination with other anti-diabetic medications (such as metformin or a sulfonylurea such as glyburide). Talk to your doctor about the risks and benefits of pioglitazone.

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