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Tacrolimus is a macrolide immunosuppressant produced by the fungus Streptomyces tsukubaensis. It suppresses both humoral and cellular immune responses. The drug inhibits a calcium/calmodulin- dependent phosphatase enzyme, calcineurin,which prevents the activation of T-cell-specific transcription factors that are involved in lymphokine expression. Other mechanisms are probably also involved in the pharmacologic and toxic effects of Tacrolimus.

Other names for this medication:
Tacrolimus, Advagraf, Envarsus, Prograf,

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Tacrolimus ointment is used to treat the symptoms of eczema (atopic dermatitis; a skin disease that causes the skin to be dry and itchy and to sometimes develop red, scaly rashes) in patients who cannot use other medications for their condition or whose eczema has not responded to another medication. Tacrolimus is in a class of medications called topical calcineurin inhibitors. It works by stopping the immune system from producing substances that may cause eczema.

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Passage of spermidine across the blood-brain barrier in short recirculation periods following global cerebral ischemia: effects of mild hyperthermia. Does aminophylline improve survival for out-of-hospital bradyasystolic arrests in adults? A retrospective method was used to compare the effect and difference between these 2 strategies. Furthermore, by controlling the aggregation state of the nanosheets, we demonstrate that the emission wavelengths can be tuned from narrow UV to broad-band white.

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Eighty-kilodalton N-terminal moiety of Bordetella pertussis filamentous hemagglutinin: adherence, immunogenicity, and protective role. Nucleoside analysis after alkaline hydrolysis of the RNA synthesized by the endogenous polymerase II suggested that the increased activity was due to a greater number of actively transcribing polymerase II molecules on the DNA. This novel method will be useful for the analysis of single-nucleotide polymorphisms present on human genes. Control of stimulus-secretion coupling in adrenal medullary chromaffin cells by microfilament-specific macromolecules.

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Plastid and mitochondrion genomic sequences from Arctic Chlorella sp. Real higher-order aberrations from normal eyes were incorporated in the model to evaluate the effect on the doublet intraocular lens performance. Several different cell types influence PC activity including excitatory input from parallel fibers and inhibition from molecular layer interneurons (MLIs).

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This study supports extension of the beneficial effects ascribed to HRT to include the peripheral arterial endothelium of healthy women. Incidence of and risk factors for febrile morbidity after laparoscopic-assisted vaginal hysterectomy. Serotype distribution of invasive Streptococcus pneumoniae in Canada after the introduction of the 13-valent pneumococcal conjugate vaccine, 2010-2012.

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Repeat measurements of nocturia during a 1-year period were analyzed using a generalized mixed linear model. PB samples and DE were analysed for both the expression of a variety of monocyte cell surface markers (CD62L, CD11b, CD25, HLA-DR, CD64 and CD14) by flow cytometry and IL-1beta levels. We present a rare case of a chondroid syringoma located in the left medial canthus of a 58-year-old man. Sensory and autonomic innervation of non-hairy and hairy human skin. Recent findings suggest that one major limitation in AMI performance is the inability to sufficiently activate neurons across the three-dimensional (3-D) IC.

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